The role of pulmonary mast cells activation and degranulation in the process of increased pulmonary artery pressure

Hypoxia exposure often cause the increases of pulmonary arterial pressure (PAP). Studies reported that mast cells (MCs) participate in vascular remodeling and promote formation chronic hypertension. Current studies mainly focus on change MCs under hypoxia, but few regulatory role mechanism acute hypoxia. T?herefore, present study investigated dynamic lung tissues hypoxia activation increasement PAP. In our study, we established an experimental rat model hypobaric using a chamber (simulated altitude 7,000 m) pretreated with degranulation inhibitor sodium cromoglycate (SCG) to changes hypoxic exposure. We found contributed increased quantity, activity, SCG pretreatment showed attenuated PAP elevation Our findings implied there is possible rapid recruitment MCs, activation, explosive release Tryptase, Chymase, IL-6, His, 5-HT, Ang II, which further microvascular contraction increase This work extends knowledge about providing potential profile as alternative treatment for high-altitude edema (HAPE)-related artery pressure.